Expression of a truncated form of KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity
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چکیده
منابع مشابه
Expression of a truncated form of KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity.
BACKGROUND TR-KIT, a truncated form of KIT (the KITL receptor), corresponding to the c-terminal half of the intracellular split tyrosine kinase domain, is expressed during the haploid stages of mouse spermatogenesis, and is one of the candidate sperm factors possibly involved in egg activation at fertilization. METHODS Immunocytochemistry of adult human testis, and studies of human semen samp...
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A truncated form of the c-Kit tyrosine kinase receptor, originally identified in mouse haploid germ cells, is aberrantly expressed in human cancer cell lines of various origin. This alternative transcript originates in the 15th intron of the human c-kit gene. We have previously demonstrated that sperm-carried mouse truncated c-Kit (tr-Kit) is a strong activator of the Src-family tyrosine kinase...
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A truncated form of the c-kit tyrosine kinase receptor, corresponding to the phosphotransferase portion of the cytoplasmic catalytic domain and the carboxyterminus (tr-kit), is accumulated during late mouse spermiogenesis. Here we report that tr-kit is specifically localized in the residual sperm cytoplasm, with maximal accumulation in the midpiece of the flagellum, suggesting that it can enter...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2010
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/deq168